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Solution-phase combinatorial synthesis of isoxazolines and isoxazoles using [2+3] cycloaddition reaction of nitrile oxides

✍ Scribed by Kyung Ho Kang; Ae Nim Pae; Kyung Il Choi; Yong Seo Cho; Bong Young Chung; Jee Eun Lee; Sun Ho Jung; Hun Yeong Koh; Hee-Yoon Lee

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
65 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient way to construct a library of isoxazoles and isoxazolines was developed by solution-phase 1,3-dipolar cycloaddition reaction of nitrile oxides with olefins and alkynes followed by precipitation of the products as HCl salts.

πŸ“œ SIMILAR VOLUMES

Synthesis of new aza-bicyclic 2-isoxazol
Synthesis of new aza-bicyclic 2-isoxazolines by 1,3-dipolar cycloaddition of endocyclic enecarbamates and enamides with nitrile oxides
✍ Valderes Moraes de Almeida; Rosiel JosΓ© dos Santos; Alexandre JosΓ© da Silva GΓ³es πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 French βš– 272 KB

Novel aza-bicyclic 2-isoxazolines, 4,5-dihydroisoxazole [5,4-b]pyrrolidines, and 4,5-dihydroisoxazole[5,4b]piperidines were synthesized in a highly regioselective manner through a 1,3-dipolar cycloaddition reaction of 5-and 6-membered endocyclic enecarbamates and enamides with several nitrile oxides