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Solution assembly of the pseudo-high affinity and intermediate affinity interleukin-2 receptor complexes

✍ Scribed by Zining Wu; Byron Goldstein; Thomas M. Laue; Stefano F. Liparoto; Michael J. Nemeth; Thomas L. Ciardelli

Book ID
111753587
Publisher
Cold Spring Harbor Laboratory Press
Year
2008
Tongue
English
Weight
450 KB
Volume
8
Category
Article
ISSN
0961-8368

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In this report, we have examined whether (6R)-tetrahydrobiopterin (H,biopterin) modulates the binding of interleukin 2 to high-affinity sites of the cloned mouse cytotoxic T-lymphocyte clone CTLL-2. Scatchard plot analysis of the equilibrium binding data reveals increased affinity when the cells are