Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor a (TNFa). Seven of 12 sera from RA patients contained TNFa, while only 1 of those from reactive arthritis patients was positive.
Soluble tumor necrosis factor receptors in human inflammatory synovial fluids
✍ Scribed by Pascale Roux-Lombard; Leonardo Punzi; Fritz Hasler; Sylvette Bas; Silvano Todesco; Harald Gallati; Pierre-André Guerne; Jean-Michel Dayer
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 477 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0004-3591
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The present study examined differentiation-inducing activity by various tumor-necrosis-factor(TNF) mutants against the human leukemic cell lines HL-60 and U-937. Mutant TNF 471, from which 7 N-terminal amino acids of native TNF were deleted and Pro 8 , Ser 9 and Asp 10 were replaced by Arg, Lys and
## Abstract ## Objective To characterize the expression pattern of tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL) and its cognate receptors (TRAIL R1, R2, R3, and R4) on rheumatoid arthritis (RA) synovial fluid (SF) lymphocytes and monocyte/macrophages and on cultured RA synovial