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Soluble Nef antigen of HIV-1 is cytotoxic for human CD4+ T cells

✍ Scribed by Yoichi Fujii; Kaori Otake; Masato Tashiro; Akio Adachi

Book ID
115932790
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
375 KB
Volume
393
Category
Article
ISSN
0014-5793

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Nef expression is not required for HIV-1 replication and is highly targeted by CD8 + CTL, raising the question of why Nef expression is not lost in order to evade immunity in vivo. We explore whether MHC class I (MHC-I) down-regulation to evade CTL in general is a selective pressure maintaining Nef.