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HIV-1 Nef Induces Dendritic Cell Differentiation: A Possible Mechanism of Uninfected CD4+ T Cell Activation

✍ Scribed by Maria Giovanna Quaranta; Elena Tritarelli; Luciana Giordani; Marina Viora


Book ID
115604256
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
205 KB
Volume
275
Category
Article
ISSN
0014-4827

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Nef is a regulatory protein of the human and simian immunodeficiency viruses (HIV and SIV) whose role in infection and the viral life cycle are not fully understood. In T‐lymphocytes Nef down‐regulates cell‐surface CD4, and has been implicated in an increase in infectivity at low primary viral isola