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Soluble Collagen VI Induces Tyrosine Phosphorylation of Paxillin and Focal Adhesion Kinase and Activates the MAP Kinase Erk2 in Fibroblasts

✍ Scribed by Martin Rühl; Manfred Johannsen; Jane Atkinson; Dirk Manski; Ergün Sahin; Rajan Somasundaram; Ernst Otto Riecken; Detlef Schuppan


Book ID
115603353
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
341 KB
Volume
250
Category
Article
ISSN
0014-4827

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✍ Padmanabhan, Jaya ;Clayton, Daniel ;Shelanski, Michael L. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 451 KB

Focal adhesion kinase (FAK or pp125FAK) is a cytosolic protein tyrosine kinase which plays an important role in integrin-mediated signal transduction. Adhesion of cells to the substratum correlates with an increase in tyrosine phosphorylation of FAK as well as an associated protein, paxillin. In thi