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Soluble Aβ oligomer production and toxicity

✍ Scribed by Megan E. Larson; Sylvain E. Lesné

Book ID
111184673
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
482 KB
Volume
120
Category
Article
ISSN
0022-3042

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## Abstract Aβ fibrils, which are central to the pathology of Alzheimer's disease, form a cross‐β‐structure that contains likely parallel β‐sheets with a salt bridge between residues Asp23 and Lys28. Recent studies suggest that soluble oligomers of amyloid peptides have neurotoxic effects in cell c