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Solubility of acetylene in aqueous solutions of formaldehyde and 2-butyne-1,4-diol

✍ Scribed by Jadkar, Pandit B.; Chaudhari, Raghunath V.


Book ID
127363879
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
285 KB
Volume
25
Category
Article
ISSN
0021-9568

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Acute toxicity of 2-butyne-1,4-diol (BYD) was evaluated in laboratory animals. The evaluation involved acute oral and dermal toxicity in rats, dermal and ocular irritation in rabbits and skin sensitization in guinea pigs. The oral L D ~~ values for BYD were 132 mg kg-' in male rats and 176 mg kg-' i

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2-Butyne-1,4-diol was given to male and female Wistar 1mp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg-' day-'. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Tr