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Quantitative determination of 2-butyne-1,4 diol in industrial aqueous solutions

✍ Scribed by V. M. Svetlaeva; I. D. Pozdnyakova; I. M. Kustanovich


Book ID
112399434
Publisher
Springer
Year
1969
Tongue
English
Weight
189 KB
Volume
3
Category
Article
ISSN
0091-150X

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Acute toxicity of 2-butyne-1,4-diol (BYD) was evaluated in laboratory animals. The evaluation involved acute oral and dermal toxicity in rats, dermal and ocular irritation in rabbits and skin sensitization in guinea pigs. The oral L D ~~ values for BYD were 132 mg kg-' in male rats and 176 mg kg-' i

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2-Butyne-1,4-diol was given to male and female Wistar 1mp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg-' day-'. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Tr