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Solubility and Stability of Cytochrome c in Hydrated Ionic Liquids: Effect of Oxo Acid Residues and Kosmotropicity

✍ Scribed by Fujita, Kyoko; MacFarlane, Douglas R.; Forsyth, Maria; Yoshizawa-Fujita, Masahiro; Murata, Kenichi; Nakamura, Nobuhumi; Ohno, Hiroyuki


Book ID
115485275
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
267 KB
Volume
8
Category
Article
ISSN
1525-7797

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## Abstract Proteins generally are only stable in vitro for short periods of time. This results in challenges during isolation and purification of recombinant proteins and reduces the shelf life of protein‐based pharmaceuticals. Here we show that certain novel, biocompatible ionic liquids provide a