Solid tumor models for the assessment of different treatment modalities-XIV: The evaluation of host and tumor response to cyclophosphamide and radiation
β Scribed by W.B Looney; H.A Hopkins; M.S Macleod; E.Russell Ritenour
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 500 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0360-3016
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π SIMILAR VOLUMES
Total radiation (4500 rad) and cyclophosphamide doses (450 mg/kg or 2.7 g/m2) were held constant over a 24-day period in rat hepatoma 3924A using radiation schedules in which 1500 rad were given over a 1-to 2-day period in 1-8 fractions, repeated at ll-day intervals, with or without cyclophosphamide
Major increases in the time between administration of two modalities, radiation and cyclophosphamide (CP), from 1 to 7 days and in the overall time of delivery of 3 courses of combined therapy from 24 to 35 days were carried out in rats with hepatoma 3924A without major loss of therapeutic effective