Solid tumor models for the assessment of different treatment modalities. XIII. Comparison of response and recovery of host and solid tumor to cyclophosphamide and radiation
β Scribed by Professor W. B. Looney; H. A. Hopkins; W. H. Grover; M. S. MacLeod; E. R. Ritenour; A. S. Hobson
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 927 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0008-543X
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π SIMILAR VOLUMES
Total radiation (4500 rad) and cyclophosphamide doses (450 mg/kg or 2.7 g/m2) were held constant over a 24-day period in rat hepatoma 3924A using radiation schedules in which 1500 rad were given over a 1-to 2-day period in 1-8 fractions, repeated at ll-day intervals, with or without cyclophosphamide
Major increases in the time between administration of two modalities, radiation and cyclophosphamide (CP), from 1 to 7 days and in the overall time of delivery of 3 courses of combined therapy from 24 to 35 days were carried out in rats with hepatoma 3924A without major loss of therapeutic effective