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Solid-Supported 2′-O-Glycoconjugation of Oligonucleotides by Azidation and Click Reactions

✍ Scribed by Kiviniemi, Anu; Virta, Pasi; Drenichev, Mikhail S.; Mikhailov, Sergey N.; Lönnberg, Harri


Book ID
111962831
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
828 KB
Volume
22
Category
Article
ISSN
1043-1802

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✍ Frank Seela; Xin Ming 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 German ⚖ 405 KB

Oligonucleotides containing 7-deaza-2'-deoxyinosine derivatives bearing 7-halogen substituents or 7-alkynyl groups were prepared. For this, the phosphoramidites 2b -2g containing 7-substituted 7-deaza-2'-deoxyinosine analogues 1b -1g were synthesized (Scheme 2). Hybridization experiments with modifi