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Solid support synthesis of 14-membered macrocycles via SNAr methodology on acrylate resin

โœ Scribed by Alexander S. Kiselyov; Shawn Eisenberg; Ying Luo

Book ID
104261072
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
302 KB
Volume
40
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Efficient assembly of 14-membered macrocycles utilizing SNAr of fluorine in 3-fluoro-4-nitrobenzoic acid with the OH of 3-hydroxytyrosine on the solid support is reported. The flexibility of this synthesis, as well as the excellent purity (>90%) of the final products are the distinctive characteristics of the resulting library.

๐Ÿ“œ SIMILAR VOLUMES

Solid support synthesis of 14- and 17-me
Solid support synthesis of 14- and 17-membered macrocycles via the SNAr methodology
โœ Alexander S. Kiselyov; Leon Smith II; Paul Tempest ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 702 KB

Efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4nitrobenzoic acid with the OH of 3-hydroxytyrosine on solid support is reported. The flexibility of this synthesis, as wel1 as the excellent purity (>90%) of the final products are the distinctive characteristi