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Solid support synthesis of 14-membered macrocycles containing 4-hydroxyproline structural unit via SNAr methodology

โœ Scribed by Marty Goldberg; Leon Smith II; Nuria Tamayo; Alexander S. Kiselyov


Book ID
118549861
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
654 KB
Volume
55
Category
Article
ISSN
0040-4020

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โœ Alexander S. Kiselyov; Shawn Eisenberg; Ying Luo ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 302 KB

Efficient assembly of 14-membered macrocycles utilizing SNAr of fluorine in 3-fluoro-4-nitrobenzoic acid with the OH of 3-hydroxytyrosine on the solid support is reported. The flexibility of this synthesis, as well as the excellent purity (>90%) of the final products are the distinctive characterist

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Efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4nitrobenzoic acid with the OH of 3-hydroxytyrosine on solid support is reported. The flexibility of this synthesis, as wel1 as the excellent purity (>90%) of the final products are the distinctive characteristi