Solid support synthesis of 14-membered macrocycles containing 4-hydroxyproline structural unit via SNAr methodology
โ Scribed by Marty Goldberg; Leon Smith II; Nuria Tamayo; Alexander S. Kiselyov
- Book ID
- 118549861
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 654 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4020
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๐ SIMILAR VOLUMES
Efficient assembly of 14-membered macrocycles utilizing SNAr of fluorine in 3-fluoro-4-nitrobenzoic acid with the OH of 3-hydroxytyrosine on the solid support is reported. The flexibility of this synthesis, as well as the excellent purity (>90%) of the final products are the distinctive characterist
Efficient assembly of 14-membered macrocycles utilizing the SNAr of fluorine in 3-fluoro-4nitrobenzoic acid with the OH of 3-hydroxytyrosine on solid support is reported. The flexibility of this synthesis, as wel1 as the excellent purity (>90%) of the final products are the distinctive characteristi