Solid State Characterization of Pharmaceuticals

• Publisher: Wiley-Blackwell
• Year: 2011
• Tongue: English
• Leaves: 517
• Category: Library

✦ Synopsis

The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.

This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. 

The following topics are included:    

• Physical properties and processes
• Thermodynamics
• Intellectual  guidance
• X-ray diffraction
• Spectroscopy Microscopy
• Particle sizing
• Mechanical properties
• Vapour sorption
• Thermal analysis & Calorimetry
• Polymorph prediction
• Form selection

Content:
Chapter 1 Introduction to the Solid State – Physical Properties and Processes (pages 1–34): Ingvar Ymen
Chapter 2 X?Ray Diffraction (pages 35–70): Chris J. Gilmore
Chapter 3 Spectroscopic Characterization (pages 71–134): Andrew O'Neil and Howell Edwards
Chapter 4 Thermal Analysis – Conventional Techniques (pages 135–186): Mark Saunders and Paul Gabbott
Chapter 5 Thermal Analysis – Dielectric Techniques (pages 187–206): Susan Barker and Milan D. Antonijevic
Chapter 6 Isothermal Calorimetric Analysis (pages 207–231): Andrew Hills
Chapter 7 Calorimetric Methods – Solution Calorimetry (pages 233–243): Simon Gaisford
Chapter 8 Vapour Sorption and Surface Analysis (pages 245–285): Jerry Y. Y. Heng and Daryl R. Williams
Chapter 9 Microscopy (pages 287–355): Gary Nichols, Shen Luk and Clive Roberts
Chapter 10 Particulate Analysis – Mechanical Properties (pages 357–386): Ron J. Roberts
Chapter 11 Particulate Analysis – Particle Size (pages 387–425): Xian?Ming Zeng
Chapter 12 Computational Polymorph Prediction (pages 427–450): Sarah L. Price and Louise S. Price
Chapter 13 Patenting of Inventions Relating to Polymorphs (pages 451–471): Bertrand Gellie, Claire Johnson and Thomas Weisbrod
Chapter 14 A ‘Roadmap’ to Solid Form Selection (pages 473–491): Richard Storey