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Solid phase synthesis of trypanothione reductase inhibitors—towards single bead screening

✍ Scribed by David Orain; Mark Bradley

Book ID: 104211553
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 80 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)02009-8

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✦ Synopsis

Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.

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