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Solid-Phase Synthesis of Substituted Guanidines Using a Novel Acid Labile Linker

✍ Scribed by Pátek, Marcel; Smrčina, Martin; Nakanishi, Eiji; Izawa, Hiroyuki

Book ID
126891864
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
154 KB
Volume
2
Category
Article
ISSN
1520-4766

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📜 SIMILAR VOLUMES

Novel linker for the solid-phase synthes
Novel linker for the solid-phase synthesis of guanidines
✍ John A Josey; Catherine A Tarlton; Courtney E Payne 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 180 KB

A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 ° or 2 ° amine affords resin