A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 Β° or 2 Β° amine affords resin
A traceless linker approach to the solid phase synthesis of substituted guanidines utilizing a novel acyl isothiocyanate resin
β Scribed by Lawrence J. Wilson; Sean R. Klopfenstein; Min Li
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 236 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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