✦ LIBER ✦
Facile solid phase synthesis of octreotide analogs using p-carboxybenzaldehyde as a novel linker to anchor Fmoc-threoninol to solid phase resins
✍ Scribed by Ying-Ta Wu; Hsing-Pang Hsieh; Chi-Yu Wu; Hui-Ming Yu; Shui-Tein Chen; Kung-Tsung Wang
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 138 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new procedure is described for the synthesis of octreotide and its analogs using p-carboxybenzaidehyde as a linker to anchor Fmoc-threoninol to solid phase resins. Fmoc-threoninol reacted with p-carboxybenzaldehyde to form Fmocthreoninol p-carboxybenzacetal in 95% yield. The Fmoc-threoninol pcarboxybenzacetal was coupled to an amine-resin and octreotides were successfully synthesized with yields of 74-76%.