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Solid-phase synthesis of selectively protected peptides for use as building units in the solid-phase synthesis of large molecules

✍ Scribed by Barton, Moira A.; Lemieux, R. U.; Savoie, J. Y.


Book ID
118030193
Publisher
American Chemical Society
Year
1973
Tongue
English
Weight
835 KB
Volume
95
Category
Article
ISSN
0002-7863

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Combined solid-phase and solution approa
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In the synthesis of large peptides or proteins, highly homogeneous segments are indispensable for a convergent strategy either on a solid-phase resin or in solution. Employing Boc/Bzl chemistry to prepare fully protected segments with a free h-carboxyl group from the solid support, base-labile linke