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Solid Phase Synthesis of Purines from Pyrimidines

✍ Scribed by Di Lucrezia, Raffaella; Gilbert, Ian H.; Floyd, Christopher D.


Book ID
125887897
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
80 KB
Volume
2
Category
Article
ISSN
1520-4766

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Microwave-assisted solid-phase synthesis
✍ Richard E. Austin; John F. Okonya; Daniel R.S. Bond; Fahad Al-Obeidi πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 73 KB

In an attempt to discover a high-throughput method for the synthesis of 2,6,9-trisubstituted purines, it was found that microwave irradiation was beneficial in accelerating the nucleophilic displacement of halogens by amines at the C-2 position of the purine nucleus. A method for microwave-assisted