Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.
โ Scribed by Hans Rink
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 237 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
Resin-bound peptides can be cleaved from the Kaiser oxime resin using the tetra-nbutylammonium salts of side-chain protected amino acids to directly provide the a-aminoprotected (Boc), side-chain protected peptide. Complete experimental details are provided. The protected peptide fragments can be pu
Solid phase peptide synthesis a8 introduced by Merrifield' and modified by others2 is proving to be a valuable addition to the tools of the peptide chemist.
In the preceding paper,1 a description of the remwal of a peptide esterified to a polystyrene resin by means of catalytic hydrogenation was presented. This method is unique in the literature concerning solid phase peptide synthesis in that blocking groups derived frcmn A-butyl alcohol are left intac