The solid phase synthesis of two phosphmwpeptides was carried out from a N-Fmoc protected dipeptide precursor containing the P-N bond and a bemy1 OT ally1 carboxylic protection easily removable under neutral conditiolls.
Solid phase synthesis of phosphonopeptides
β Scribed by Jean-Marc Campagne; Jacques Coste; Patrick Jouin
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 170 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Phosphopeptides are a useful tool for the investigation of phosphorylation as a reversible posttranslational modification. There is a growing interest in using mimics of phosphoamino acids involved in phosphorylation in order to study the enzymes concerned in these processes. These mimics should con
The formation of a-amino phosphonate functionalities on the amino terminus of peptides utilizing solid-phase methodology is presented. The described method enables incorporation of diverse N-phosphonoalkyl and aryl moieties.
A direct method for the preparation of phosphonamidate- and phosphonate-linked phosphonopeptides has been developed. Using this method, both phosphonopeptides were prepared in acceptable yields directly from simple and commercially available chemicals in one-pot reactions of benzyl carbamate, aldehy