𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin

✍ Scribed by Dries B.A de Bont; Gerard D.H Dijkstra; Jack A.J den Hartog; Rob M.J Liskamp

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
377 KB
Volume
6
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.

✦ Synopsis

Using Boc or Fmoc-protected ~-substituted aminoethanesulfonyl chlorides (2substituted taurylchlorides) the solid-phase synthesis of dipeptidosulfonamides as well as peptidosulfonamide containing peptides derived from Leu-enkephalin is described. The binding activity of the peptidosulfonamide YGGFL derivatives is reported.

📜 SIMILAR VOLUMES

Automated Solid-Phase Synthesis and Stru
Automated Solid-Phase Synthesis and Structural Investigation of β-Peptidosulfonamides and β-Peptidosulfonamide/β-Peptide Hybrids: β-Peptidosulfonamide and β-Peptide Foldamers are Two of a Different Kind
✍ Remco de Jong; Dirk T. S. Rijkers; Rob M. J. Liskamp 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 German ⚖ 321 KB

## Abstract Fmoc‐protected __β__‐aminoethane sulfonylchlorides can be employed for efficient automated solid phase synthesis of __β__‐peptidosulfonamides and __β__‐peptidosulfonamide/__β__‐peptide hybrids containing one or more __β__‐peptidosulfonamide residues. Thus, Fmoc‐protected __β__‐aminoetha

Solid phase synthesis of a cyclic peptid
Solid phase synthesis of a cyclic peptide derived from a curaremimetic toxin
✍ Anne Tromelin; Marie-Hélène Fulachier; Gilles Mourier; André Ménez 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 248 KB

We synthesized a 18 residues cyclic ppcicle correqonding to a loop involved in tk cumremimetic action of a snake toxic pmtein. This peptide. whii ccnn~les with Ihe native toxin for the binding lo the nicolinic ucetylcholii mzeptor, inclti the Bturn inducing Pro-AW moiety. Gibe peptide wax pqxued and

Hydrogenation of protected leucine enkep
Hydrogenation of protected leucine enkephalin from a resin during solid phase synthesis
✍ David A. Jones Jr. 📂 Article 📅 1977 🏛 Elsevier Science 🌐 French ⚖ 228 KB

In the preceding paper,1 a description of the remwal of a peptide esterified to a polystyrene resin by means of catalytic hydrogenation was presented. This method is unique in the literature concerning solid phase peptide synthesis in that blocking groups derived frcmn A-butyl alcohol are left intac

Solid-Phase Synthesis of Peptides Contai
Solid-Phase Synthesis of Peptides Containing Reverse-Turn Mimetic Bicyclic Lactams
✍ Cesare Gennari; Antonia Mielgo; Donatella Potenza; Carlo Scolastico; Umberto Pia 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 2 views

The solid-phase synthesis and characterization of a series of accomplished by means of diisopropylcarbodiimide (DIC)/ hydroxyazabenzotriazole (HOAt). Coupling between amino peptides (4-15) containing reverse-turn mimetic bicyclic lactams is reported. The bicyclic lactams (1a, 1b) possess acids and t

A new flourene-derived anchor for solid-
A new flourene-derived anchor for solid-phase synthesis of protected peptides
✍ Francesc Rabanal; Ernest Giralt; Fernando Albericio 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 298 KB

N-[9-(hydroxymethyl) .2.tluorenyl] succinamic acid may be used as an anchoring linkage for the preparation of protected peptide segments in combination with Boc/Bzl' protection scheme. The new handle proved to be stable to the usual conditions of solid-phase peptide synthesis and gave the protected