Solid-phase synthesis of peptides with C-terminal asparagine or glutamine
β Scribed by ALBERICIO, FERNANDO ;ABEL, ROBERT ;BARANY, GEORGE
- Book ID
- 115099074
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 261 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0367-8377
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## Abstract Solidβphase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for
## Abstract In this paper, a straightforward and generic protocol is presented to label the __C__βterminus of a peptide with any desired moiety that is functionalized with a primary amine. Amineβfunctional molecules included are polymers (useful for hybrid polymers), long alkyl chains (used in pept