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Solid phase synthesis of peptides containing a phosphoserine - sulfur mustard adduct

✍ Scribed by D. Noort; D.H.J.M. Platenburg; H.P. Benschop


Book ID
108039047
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
344 KB
Volume
6
Category
Article
ISSN
0960-894X

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A building block method for the SPPS of serine phosphopeptides has been developed using a combination of Fmoc and Alloc strategies. AIIoc-Ser[PO(OCH2CH=CH2)2]-OH , prepared in a one-pot procedure from Alloe-Ser-OH, was introduced at the Nterminus of a sequence prepared by standard Fmoc-SPPS. Global