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Solid-Phase Synthesis of Peptide Vinyl Sulfones as Potential Inhibitors and Activity-Based Probes of Cysteine Proteases

โœ Scribed by Wang, Gang; Mahesh, Uttamchandani; Chen, Grace Y. J.; Yao, Shao Q.


Book ID
126770559
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
77 KB
Volume
5
Category
Article
ISSN
1523-7060

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Solid phase synthesis of peptide vinyl s
โœ Herman S Overkleeft; Pepijn R Bos; Brian G Hekking; Eva J Gordon; Hidde L Ploegh ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 193 KB

The solid phase synthesis of the known proteasome inhibitor ZL 3 VS, using Kenner's safety catch protocol, is described. This methodology has been extended to the synthesis of various novel peptide vinyl sulfone and peptide epoxyketone derivatives.