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Solid-Phase Synthesis of Novel Amino-Ether Derivatives

✍ Scribed by Paul S. Furth; Michael S. Reitman; Robert Gentles; Alan F. Cook

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
608 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Tbree amino-ether derivativeshavebeenpreparedby a solid-phaae synthesisusinga novelamidine-based linker.The sequenceof reactionsinvolveda) amineexchangeof a solidsupporteddimethylfonnmnidine witha secondaryamine,b) et-alkylation of tbe solid-supported fortnamidine withanaromaticatdehyde, c) alkylation of thenewlygenerated hydroxyl groupwitba benzylichalide, andd)cleavage oftheformamidine linkagetothesolidsupport. 01997 ElsevierScienceLtd.

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