Biphenyltetrazoles are recognized privileged structures. Among them, the therapeutically important class of sartans displays antagonistic activity on AT1 receptors. We have developed a method for anchoring tetrazole derivatives via the heterocycle on a hydroxylated resin using zinc triflate. New Suz
Solid phase synthesis of biphenyltetrazole derivatives
โ Scribed by Sung-eun Yoo; Jin-soo Seo; Kyu-yang Yi; Young-dae Gong
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 172 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
A dihydropyran carboxylic acid type linker is suitable for the solid phase Suzuki type aryl-aryl coupling reaction for the preparation of various biphenyltetrazole derivatives.
๐ SIMILAR VOLUMES
A novel solid-phase synthetic method for dehydroalanines and dehydropeptides has been developed. Elimination of the sulfone part with concomitant release from the solid support afforded the desired dehydroalanine derivatives. The products were given in good yields and excellent purities.
A novel method for solid-phase synthesis of dihydroquinazoline derivatives is presented. Polymer-bound 4-bromomethyl-3-nitrobenzoate and the corresponding amide are utilized as versatile precursors that undergo nucleophilic displacement with amines followed by reduction and cyclocondensation reactio