✦ LIBER ✦

Solid-phase synthesis of 3,4-dihydroquinazoline derivatives

✍ Scribed by Jinfang Zhang; Julie Barker; Boliang Lou; Hossain Saneii

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 92 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01842-1

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✦ Synopsis

A novel method for solid-phase synthesis of dihydroquinazoline derivatives is presented. Polymer-bound 4-bromomethyl-3-nitrobenzoate and the corresponding amide are utilized as versatile precursors that undergo nucleophilic displacement with amines followed by reduction and cyclocondensation reactions to afford structurally diverse dihydroquinazolines with excellent yield and purity.

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