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Solid-Phase Synthesis of N -Aryl Succinimides

โœ Scribed by Rad-Moghadam, Kurosh; Kheyrkhah, Leila


Book ID
118262361
Publisher
Taylor and Francis Group
Year
2009
Tongue
English
Weight
154 KB
Volume
39
Category
Article
ISSN
0039-7911

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An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin