✦ LIBER ✦

Solid-phase synthesis of modified oligodeoxyribonucleotides with an acridine derivative or a thiophosphate group at their 3′end

✍ Scribed by U. Asseline; Nguyen T. Thuong

Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 314 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)80440-8

No coin nor oath required. For personal study only.

✦ Synopsis

Use

of a derivatized support involving the 2,2'-diethyldithio-group 1 SllOWS the automated synthesis of oligodeoxyribonucleotide bearing acridine derivative (via nucleoside-3'acridinylphosphoramidite 2) or 3'phosphorothioate group (including the sulfurization step fOJ2 attachment of the first nucleoside to the support).

📜 SIMILAR VOLUMES

Solid phase synthesis of 5',3'-bifunctio

Solid phase synthesis of 5',3'-bifunctional oligodeoxyribonucleotides bearing a masked thiol group at the 3'-end

✍ E. Bonfils; N.T. Thuong 📂 Article 📅 1991 🏛 Elsevier Science 🌐 French ⚖ 257 KB

Synthesis of oligonucleotides containing

Synthesis of oligonucleotides containing a carboxyl group at either their 5′ end or their 3′ end and their subsequent derivatization by an intercalating agent

✍ Marina Gottikh; Ulysse Asseline; Nguyen T. Thuong 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 258 KB

The attachment of an unprotected aminoacid either at the 5' end of an oligonucleotide v&a a carbamate linkage or at the 3' end via a phosphoramidate bond leads to modified oligonucleotides containing carboxyl group via alinker. These carboxyl groupscan then specifically react with the primary amino