✦ LIBER ✦
Synthesis of oligonucleotides containing a carboxyl group at either their 5′ end or their 3′ end and their subsequent derivatization by an intercalating agent
✍ Scribed by Marina Gottikh; Ulysse Asseline; Nguyen T. Thuong
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 258 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The attachment of an unprotected aminoacid either at the 5' end of an oligonucleotide v&a a carbamate linkage or at the 3' end via a phosphoramidate bond leads to modified oligonucleotides containing carboxyl group via alinker. These carboxyl groupscan then specifically react with the primary amino group ofxunomycin in the presence of carbodiimide.