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Solid-Phase Synthesis of Lactose-Containing Oligosaccharides

✍ Scribed by Fabien Roussel; Laurent Knerr; Richard R. Schmidt

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
389 KB
Volume
2001
Category
Article
ISSN
1434-193X

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✦ Synopsis

The new lactosyl donor 8, bearing an Fmoc-protected hydroxy group, has been prepared from lactose for the solidphase synthesis of lactose-containing oligosaccharides. In addition to the preparation of 3b-O-fucosyllactoside 1 (with donor 4), use of this new building block has permitted the syntheses of 3b-O-mannosyllactoside 2 and of human milk [a

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