Acetophenone-based linker for solid-phas
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Chinh T. Bui; Andrew M. Bray; Thao Nguyen; Francesca Ercole; Firas Rasoul; Wayne
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Article
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2000
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John Wiley and Sons
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English
β 126 KB
π 2 views
A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhaseβ’ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluor