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Solid phase synthesis of benzimidazoles

✍ Scribed by Gary B. Phillips; Guo Ping Wei


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
204 KB
Volume
37
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Solid-phase synthesis of substituted ben
✍ David Tumelty; Matthias K. Schwarz; Kathy Cao; Michael C. Needels πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 216 KB

A solid-phase synthesis of benzimidazoles, substituted on the aromatic ring by a variety of groups or atoms, is described. Intermediate 3, derived from the acylation of a resin-bound secondary amine with Fmoc-glycine, was elaborated via nucleophilic displacement with substituted o-halonitroarenes to

Solid-phase synthesis of benzimidazole N
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A solid-phase synthesis of benzimidazole N-oxides was developed while attempting to synthesize 1,5-benzodiazepine-2,4-diones. The key step of the synthesis involves the reduction of an arylnitro to a hydroxyamino intermediate which subsequently condenses with an internal carbonyl group to give a ben