✦ LIBER ✦

Solid phase synthesis of azapeptides utilising reversible amide bond protection to prevent hydantoin formation

✍ Scribed by Mark Liley; Tony Johnson

Book ID: 104210309
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 92 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00534-7

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✦ Synopsis

An efficient method for the solid phase assembly of 'aza-peptides' is described using Fmoc/tert-butyl chemistry. Elimination of unwanted hydantoin side product is achieved with the use of Hmb reversible amide bond protection.

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