Solid-phase synthesis of 4-aryl substituted 5-carboxy-6-methyl-3,4-dihydropyridones
✍ Scribed by Hortensia Rodrı́guez; Osvaldo Reyes; Margarita Suarez; Hilda E. Garay; Rolando Pérez; Luis Javier Cruz; Yamila Verdecia; Nazario Martı́n; Carlos Seoane
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 110 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Substituted 3,4-dihydro-2-pyridones have been efficiently prepared by solid-phase synthesis using Wang resin from the immobilised b-ketoester and further Hantzsch-type heterocyclisation.
📜 SIMILAR VOLUMES
A simple and practical route for the asymmetric synthesis of (S)-4-(4-fluorophenyl)-1,4,5,6-tetrahydro-6oxo-3-pyridinecarboxylic acid (1) is presented. The procedure comprises catalytic desymmetrization of a meso-anhydride using a chiral thiourea organocatalyst, followed by selective formylation and
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