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Solid-Phase Synthesis of 3-Alkylamino-1,2,4-triazoles

โœ Scribed by Makara, Gergely M.; Ma, Yao; Margarida, Laura


Book ID
121316160
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
52 KB
Volume
4
Category
Article
ISSN
1523-7060

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An efficient solid-phase synthesis of 3-
โœ Gergely M Makara; Peter Schell; Kelley Hanson; Dennis Moccia ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 95 KB

A solid-phase synthesis of substituted 3-alkylamino-1,2,4-oxadiazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydroxylamine under mild conditions furnished the oxadiazole skeleton regioselectively in hig