SOLID-PHASE SYNTHESIS OF 2,4,6-TRIAMINOPYRIMIDINES
β Scribed by Yoo, Kyung Ho; Kim, Sung Eun; Shin, Kye Jung; Kim, Dong Chan; Park, Sang Woo; Kim, Dong Jin
- Book ID
- 118038942
- Publisher
- Taylor and Francis Group
- Year
- 2001
- Tongue
- English
- Weight
- 124 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0039-7911
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An effective traceless solid-phase synthesis of chloro-diaminopyrimidines via an amino-de-chlorination reaction of polymerbound 4-alkoxycarbonylamino-2,6-dichloropyrimidines has been developed. After release from the polymer the target molecules were obtained in good to excellent purity, although wi
The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawesson's reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in go