Solid phase synthesis of 1-alkyl-2-alkylthio-5-carbamoylbenzimidazoles
โ Scribed by Jung Lee; Diane Gauthier; Ralph A. Rivero
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 165 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
A solid-phase synthesis ofpolysubstituted 1,5-benzodiazepin-2-ones is described. Resinbound 4-fluoro-3-nitrobanzoic acid was reacted with different ~amino acids, followed by nitro group reduction and formation of the seven-membered ring. Subsequent alkylations at N(5) and N(1) afforded the title com
A solid-phase synthesis that provides easy access to 2-amino-5-sulfanylthiazoles with variable substituents at C-2, C-4, and C-5 has been developed. The key step of this synthesis is a new C-sulfanylation of resin-bound 2-aminothiazoles by mixtures of various sulfur-containing building blocks and io