Solid-phase synthesis and 1H and 13C high-resolution magic angle spinning NMR of 13C-labeled resin-bound saccharides

✍ Scribed by Nikolaus M. Loening; Takuya Kanemitsu; Peter H. Seeberger; Robert G. Griffin

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 445 KB
• Volume: 42
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.1364

✦ Synopsis

Abstract

We show how high‐resolution magic angle‐spinning NMR spectroscopy can be used to characterize ^13^C‐labeled saccharides that have been prepared using solid‐phase synthesis techniques while they are still bound to a solid‐support resin. With the use of ^13^C‐labeled glucose as the starting material, we have successfully synthesized mono‐, di‐ and trisaccharides with uniform ^13^C labeling of the saccharide rings. Using these materials, we have been able to assign the ^13^C and ^1^H spectra and to characterize various impurities on the resin beads. Copyright © 2004 John Wiley & Sons, Ltd.