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Solid phase peptide synthesis using a cobalt(III) spacer between the resin and the peptide

✍ Scribed by Mensi, Nahla; Isied, Stephan S.


Book ID
125990450
Publisher
American Chemical Society
Year
1987
Tongue
English
Weight
420 KB
Volume
109
Category
Article
ISSN
0002-7863

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The use ofnucleophiles for the cleavage of an o-nitrobenzylester peptide-resin bond in order to afford peptide alkylesters and alkylamides has been studied. With this purpose, three short peptide sequences anchored to a Nbb-resin were used as models. Peptides were cleaved from the polymeric supports

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## Synopsis Attachment of the side-chain carboxyl of the protected aspartic or glutamic acid ester to the resin support has been established for the solid-phase synthesis of the asparagine or glutamine peptide. After further elongation of the a-amino deprotected resin-bound peptide ester with prot