✦ LIBER ✦

Solid-phase microextraction (SPME) and gas-chromatographic analysis of anorectic compounds in human urine

✍ Scribed by Marcello Chiarotti; Sabina Strano-Rossi; Remo Marsili

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 64 KB
Volume: 9
Category: Article
ISSN: 1040-7685
DOI: 10.1002/(sici)1520-667x(1997)9:4<249::aid-mcs1>3.0.co;2-1

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✦ Synopsis

Solid-phase microextraction SPME has been applied to the analysis of anorectic compounds from human urine. Urine samples from phendimetrazine and fenfluramine users, after the 1:1 dilution and addition of 400 ngrmL of Proadifen as an internal standard, have been directly sampled with SPME and analyzed by gas chromatographyrmass spectrometry. Calibration curves have been built by spiking blank urine with amounts ranging from 60 to 900 ngrmL for fenfluramine and from 80 to 800 ngrmL for phendimetrazine. Correlation coefficients were 0.992 for phendimetrazine and 0.995 for fenfluramine curve. On 10 replicate samples, variation coefficients of 8% and 10% were observed for phendimetrazine and fenfluramine, respectively.

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