An efficient solid-phase synthesis of asymmetric cyanine dyes is described. Combinatorial synthesis and spectroscopic analysis of four dyes was carried out. The yields are quantitative after 20 h, but the reaction can be halted earlier, since it is shown that the starting material does not disturb t
โฆ LIBER โฆ
Solid-Phase Methods for the Synthesis of Cyanine Dyes
โ Scribed by Mason, Stephen J.; Hake, Jen L.; Nairne, James; Cummins, W. Jon; Balasubramanian, Shankar
- Book ID
- 121006465
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 403 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3263
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## Abstract The synthesis of the chiral monomethine cyanine dyes 8 and 9 starting with the achiral indole 1 is described. Key intermediates are the new chiral Fischer bases __R__โ and __S__โ4, which were separated after diastereomeric salt formation. The conformation of the dyes 8 and 9 is twisted