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Solid-Phase Methods for the Synthesis of Cyanine Dyes

โœ Scribed by Mason, Stephen J.; Hake, Jen L.; Nairne, James; Cummins, W. Jon; Balasubramanian, Shankar


Book ID
121006465
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
403 KB
Volume
70
Category
Article
ISSN
0022-3263

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An efficient solid-phase synthesis of asymmetric cyanine dyes is described. Combinatorial synthesis and spectroscopic analysis of four dyes was carried out. The yields are quantitative after 20 h, but the reaction can be halted earlier, since it is shown that the starting material does not disturb t

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## Abstract The synthesis of the chiral monomethine cyanine dyes 8 and 9 starting with the achiral indole 1 is described. Key intermediates are the new chiral Fischer bases __R__โ€ and __S__โ€4, which were separated after diastereomeric salt formation. The conformation of the dyes 8 and 9 is twisted