Solid-phase Friedel–Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones

✍ Scribed by Francesca Bevacqua; Andrea Basso; Rosaria Gitto; Mark Bradley; Alba Chimirri

• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 101 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)01602-1

✦ Synopsis

Friedel-Crafts acylation with various acyl chlorides of resin-bound 3,4-dimethoxyphenylacetate afforded resin bound ketones which, following treatment with hydrazine, were converted into the corresponding 2,3-benzodiazepines in good yields and purities.