Solid-phase extraction and analysis of paroxetine in human plasma by ultra performance liquid chromatography–electrospray ionization mass spectrometry
✍ Scribed by Mitesh Bhatt; Sanjay Shah; Shivprakash
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 312 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0269-3879
- DOI
- 10.1002/bmc.1275
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## Abstract A rapid, sensitive and specific high‐performance liquid chromatography–electrospray ionization mass spectrometry (LC‐ESI‐MS) method has been developed and validated for the determination of oxatomide in human plasma. Flunarizine hydrochloride was employed as the internal standard (IS).
Disaccharides and linear oligosaccharides were labeled with p-aminobenzoic ethyl ester (ABEE) chromophore and analyzed by negative ion electrospray ionization mass spectrometry (ESIMS). The formation of glycosylamines rather than reductive amination in the labeling reaction produced many characteris