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Solid-Phase Chemistry in the Total Synthesis of Non-Peptidic Natural Products

โœ Scribed by Pablo Cironi; Mercedes Alvarez; Fernando Albericio


Publisher
John Wiley and Sons
Year
2006
Weight
8 KB
Volume
37
Category
Article
ISSN
0931-7597

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โœ Maria L. Diss; Alan J. Kennan ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 193 KB ๐Ÿ‘ 1 views

## Abstract A method is reported for the straightforward generation of ureaโ€containing peptides during Boc solid phase peptide synthesis. Primary amine side chains are converted to monoโ€alkyl ureas in two steps via an intermediate __p__โ€nitrophenyl carbamate. Use of __p__โ€methoxybenzyl amine as an