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Solid Phase Chemistry: Direct Monitoring by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. A Tool for Combinatorial Chemistry

✍ Scribed by Egner, Bryan J.; Langley, G. John; Bradley, Mark


Book ID
125999714
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
260 KB
Volume
60
Category
Article
ISSN
0022-3263

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This study presents matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) as a powerful tool to analyze and characterize oligonucleotides covalently linked to a solid support during their synthesis. The analysis of the fragment ions generated either in negative o